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Philp D, et al
MET forms clusters at excitatory synapses in relatively mature cultured hippocampal neurons and co-localizes with the post-synaptic protein PSD-95 and with the glutamatergic N-methyl-D-aspartate (NMDA) receptor subunit GluN2B ( in vitro and in vivo methods to examine how altered MET signaling impacts synaptic development, observing an opposite effect on neuronal morphology in a stage-dependent way
Interestingly, a trial with adalimumab was terminated early [106]
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