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Covariates Covariates included age, sex, educational level (as total year of formal education), obtained from structured interviews conducted at the beginning of the study, as well as metabolomic assessment shipment (first vs second)
(Reuters) Known risk factors for NAION include: Diabetes High blood pressure High cholesterol Sleep apnea Smoking Medications that affect blood flow or circulation Because GLP-1 drugs influence metabolic function, blood sugar levels, and physiological processes that may affect circulation, plaintiffs in GLP-1 lawsuits allege that drug manufacturers knew or should have known about the potential risk of optic nerve damage and failed to adequately warn patients and healthcare providers
In comparison, albiglutide, dulaglutide, and semiglutide are human-GLP-1 based analogs
Animals were daily administered (s.c.) with optimal doses of the different GLP1-based multi-agonists or vehicle (saline) for 28 consecutive days
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