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When a single dose (0.2 mg/kg) daily for 3 days (0.3 mg/kg) of PQQ was administered to 10 young participants (five males and five females), the levels of trimethylamine N-oxide, a marker of perturbed energy metabolism, decreased following PQQ intake
Its primary mechanism runs through AMPK activation
Abbreviations ARE: Antioxidant responsive element CDNB: 1-chloro-2,4-dinitrobenzene CYS: Cysteine DAPI: Diamidine-2-phenylindole-dihydrochloride DMF: Dimethylfumarate DTNB: 5,5-dithiobis(2-nitrobenzoic acid) GPX: Glutathione-peroxidase GSH: Reduced form of glutathione GST: Glutathione-S-transferase MCB: Monochlorobimane NADPH: Nicotinamide adenine dinucleotide phosphate Nrf2: Nuclear factor (erythroid-derived 2)-like 2 PBS: Phosphate buffered saline PXR: Pregnane-X-receptor RT: Room temperature TBS-T: Tris-buffered saline supplemented with 1% Tween 20 References Saunders NR, Dziegielewska KM, Mollgard K, Habgood MD, Wakefield MJ, Lindsay H, et al
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