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I get far more excited about helping patients reduce or eliminate medications than the number on the scale.
With respect to the wider GLP-1 drug class, the UK SmPCs for semaglutide (available on the electronic Medicines Compendium, emc) and tirzepatide (Mounjaro SmPC, emc) document GI adverse effects including nausea, vomiting, diarrhoea, constipation, and dyspepsia as well-characterised class effects
In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) has licensed these medications for specific uses, usually involving the management of type 2 diabetes or as a support for weight loss in individuals with a high BMI and weight-related health complications
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I have seen patients with chronic nausea and vomiting on (semaglutide), which can cause dehydration and malnutrition if you cant get enough calories or fluids daily, registered dietitian Emily Rubin, director of clinical dietetics in the division of gastroenterology and hepatology at Thomas Jefferson University Hospital in Philadelphia, previously told TODAY.com
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