A pre-bed dose is timed to reinforce that natural nocturnal pulse, which is why the pre-bed slot is the one most consistently kept even in a once-daily schedule
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some individuals may be over- or under-reactive to lights, sounds, textures, or tastes
Notably, a marginal increase in risk (RR 1.34, 95% CI 1.04, 1.72) was observed in studies with methodological flaws 41
Once the normality assumptions were confirmed, we employed paired t-tests to compare the degree centrality between the PEA and vehicle groups in various subregions