Por otra parte, el GLP-1 circulante penetra en reas circunventriculares del SNC como el rgano subfornical, rgano vasculosum de la lmina terminalis, la eminencia media prxima al ncleo arcuato y el rea postrema, merced a la permeabilidad parcial de la barrera hematoenceflica2,3,6
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Studies suggest that the copper(II) ion is essential for biological activity, as the apo-peptide (GHK without copper) shows reduced activity
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