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With semaglutide (at its authorized obesity dose), many patients in trials lost around 14-15% of starting body weight over ~68-72 weeks vs placebo

CrossRef Lieberman JA, Stroup TS, McEvoy JP, et al

Much of the slowdown in the fourth quarter was attributed to Regenerons COVID-19 drug Ronapreve (casirivimab/imdevimab)

Id rather see people stay on them and maintain their weight loss. Can dialed-in nutrition and strength training help someone keep the weight off

Experimental studies provide strong evidence that insulin resistance-related neuroinflammation feeds cognitive impairment neuropathology, leading to a raised-up brain levels of pro-inflammatory cytokines (Mullins et al., 2017