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Additional searches of conference proceedings (from the last 3 years), health technology assessment (HTA) body websites, clinical trial registries (ClinicalTrials.gov and World Health Organization International Clinical Trials Registry Platform), and reference lists of included studies were performed to identify other relevant evidence
In those, loss of NRF2 resulted in a more rapid onset and more severe clinical course of the EAE model, which was accompanied by increased glial activation, exacerbated spinal cord damage, and axonal degeneration as well as increased levels of proinflammatory cytokines (Johnson et al., 2010
Some patients remain effective at lower doses, while others benefit from continuing to 1.7 mg or 2.0 mg for enhanced results