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As expected, H 2 O 2 (0.2 mM) exposure disrupted cellular glutathione homeostasis in both HepG2 cells (a human hepatoma cell line) and NCTC1469 cells (a non-transformed mouse hepatocyte cell line), as demonstrated by an increase in the GSSG/GSH ratio over time (Fig
These mediators initiate inflammatory cascades in part by altering epigenetic regulators such as DNA methyltransferases, histone modifiers, and noncoding RNAs (Sanchez-Lopez et al., 2022
In the latter form, it is not produced for human ingestion or unsupervised self-administration
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