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Targeting inflammation and necroptosis in diabetic kidney disease: a novel approach via PPAR modulation
Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells ( As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) (Yang et al., 2022a)
Peptides Containing Glutamine or Asparagine These amino acids are susceptible to deamidation
A controversy is cited in the literature regarding the specificity of TBARS toward compounds other than MDA (malondialdehyde)
