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While these self-care measures often prove sufficient, consulting a healthcare provider becomes essential if symptoms persist or interfere with daily activities

577 Conversely, non-pharmacological interventions, such as bladder training with scheduled voiding and pelvic floor exercises, along with intermittent catheterization, are essential to prevent urinary retention and reduce infection risks

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These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects