tirzepatide ckd trial Putative mechanisms underlying the renal benefits of tirzepatide. In SURPASS-4: Tirzepatide slows kidney disease

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This results in chronic hypercortisolism, adrenocortical hyperplasia, glucose intolerance and mature-onset obesity, resembling human Cushings syndrome 64

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Treatment should be discontinued if the 3.0 mg dose cannot be tolerated

Their current strategy is to contain near-term expenses while waiting for clearer long-term data and possible price competition (including generics or biosimilars)