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Someone with a GIPR rs1800437 variant that strongly activates the glucose-dependent insulinotropic polypeptide pathway, for example, might get more powerful results from tirzepatide than from semaglutide alonewithout ever needing phentermine's cardiovascular stress

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Vallance HD, Koochin A, Branov J, Rosen-Heath A, Bosdet T, Wang Z, Hazen SL, Horvath G

Large cardiovascular outcome trials, including LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide), have provided valuable insights into lipid changes