Weeks 5-12 (mid-titration): With each dose increase, there's a recurrence of GI symptoms at a similar but sometimes milder intensity your system has adapted somewhat
Some patients unintentionally eat far too little
It can be hard to stay on top of planning meals, cooking, and exercising regularly
J Endocrinol 190:669680 Miki T, Minami K, Shinozaki H, Matsumura K, Saraya A, Ikeda H, Yamada Y, Holst JJ, Seino S (2005) Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility
Any of these scenarios may prompt a dose adjustment up, down, or in some cases a planned, gradual discontinuation with a bridge protocol to prevent rebound