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CntA/B is a notoriously hard enzyme to study, but once it was stabilized, we were able to gain insight into how CntA perceives its L-carnitine substrate with a 3D crystal structure model, and by studying the complete electron transfer pathway, we could see how the protein is able to turn over TMA
Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, et al
The authors suggest creatine may: Help maintain lean muscle mass Improve strength and functional capacity Support glucose control Potentially reduce inflammation Importantly, this is not yet supported by clinical trials in people taking GLP-1 medications
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