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Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]
Jeffrey Lee, MD, a double board-certified plastic surgeon and founder of JL Plastic Surgery in Boston, MA, who was not involved in the study, spoke to Healthline about these hidden side effects, why they may occur, and what people may misunderstand about GLP-1s from social media posts
*Correspondence: Tricia M
One study found that after injecting high doses of vitamin B12 (specifically cyanocobalamin) into rodents, the B12 stayed in the bloodstream for a relatively short period, with a half-life ranging from 20 to 50 minutes
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