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Dall TM, Yang W, Halder P, et al

avoid foaming or vigorous agitation

Reduce the area under the curve (AUC) which represents the total drug exposure over time

During weight loss, especially when appetite is suppressed, higher intakes are advisable and evidence suggests a range of 1.21.6g per kilogram of body weight per day supports lean mass retention during energy restriction 4

These guidelines help ensure that the medication is prescribed to individuals who are most likely to benefit from its weight-reducing effects