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Medications like semaglutide and tirzepatide mimic or enhance these signals, helping people eat less and feel satisfied longer
The ESSENCE trial 240-week readout in 2028 will be a landmark, but longer follow-up and adequately powered studies in higher-risk populations (F3-F4 fibrosis) remain priorities
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RealFits approach pairs GLP-1 therapy with protein-first nutrition, lifestyle coaching, and progress monitoring to protect lean muscle and improve outcomes
Cold Intolerance: Increased sensitivity to cold temperatures
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