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In contrast, resmetirom targets hepatic THR- directly, improving intrahepatic lipid handling and fibrogenesis, with minor effects on systemic weight [Figure 1C]

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Reactive oxygen species, cellular redox systems, and apoptosis

Weight loss itself can cause transient transaminase elevations as hepatic fat mobilizes, a phenomenon well-documented in bariatric surgery literature and now recognized in pharmacologic weight-loss settings