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In addition, early reports of suicidality associated with these agents resulted in regulatory investigations concluding that cause and effect cannot be established but should continue to be a variable for further evaluation.Reference McIntyre, Mansur, Rosenblat and Kwan 24 , Reference McIntyre, Mansur and Rosenblat 51 Reference Wang, Volkow, Berger, Davis, Kaelber and Xu 53 In conclusion, our overarching aim is to encourage comprehensive assessments of whether semaglutide (and/or other incretin receptor agonists) is capable of exerting nephroprotective effects in persons exposed to lithium
The GIP receptor component is believed to enhance metabolic and weight-loss effects, whilst glucagon receptor activation is hypothesised to increase energy expenditure and promote hepatic fat breakdown (lipolysis)
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