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These metabolites have possibly important implications for any future treatment of metabolic pathologies such as type 2 diabetes, where our understanding of the pharmacokinetic and pharmacodynamics in humans is virtually absent (128)
When paired with metabolic biomarkers, product potency assays and long-term functional endpoints, cell therapy may become a rational metabolic adjunct to reperfusion and rehabilitation
Eur Heart J 42:152161
Fortunately, melanotic macules are harmless
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