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When fat stores go down, leptin levels also go down
However, dual agonists, such as glucose-dependent insulinotropic polypeptide receptor (GIPR)/GLP-1R and glucagon receptor (GCGR)/GLP-1R dual agonists, have the potential for enhanced therapeutic efficacy and improved tolerability compared with GLP-1R mono-agonists, owing to their multiple mechanisms of action [5, 6]
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A secondary objective was to determine the extent to which these predictions could support the optimization of trial design parameters
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