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The proportion of participants achieving MWPC ( 5.76) in the SF-36v2 physical functioning score from baseline to week 72 was numerically higher with tirzepatide 10 mg (34.2%) and 15 mg (35.6%) than with placebo (24.1%

Collectively, the functional states of macrophages extend beyond the simplistic M1/M2 framework, forming a multidimensional continuum shaped by signaling networks, epigenetic regulation, and metabolic reprogramming, which profoundly influences their diversity and adaptability in both physiological and pathological contexts

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