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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

Accumulating evidence suggests that PAG neurons also control energy balance

The cells were incubated at 37 C without 5% CO 2 for 1 h to allow media temperature and pH to reach equilibrium before the first rate measurement

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2014 Phase II trial (117 bowel surgery patients, NCT00672074), ipamorelin given as 0.03 mg/kg IV twice daily for up to 7 days produced treatment-related adverse event rates similar to placebo