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Diagnostic criteria used in AD and MCI AD patients were identified primarily using the Diagnostic and Statistical Manual of Mental Disorders (DSM) [63] and/or the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimers Disease and Related Disorders Association [64]
But the real clinical point is timing: intervening late means compressing the observable benefit, whereas earlier use can modify the trajectory of disease
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Despite the work being focused on diabetic rats and no anti-obesogenic assays being performed, metformin has proved to have anti-obesogenic effects, and therefore, this approach has a great potential for obesity treatment ( 4.4 Other materials (gelatin, silicone) Besides HA, PLGA, PVA, and PVP, other polymers have been used for MP with anti-obesogenic activity
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