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Chronic oxidative stress in the brainstem and peripheral nerves keeps the autonomic nervous system locked in a state of sympathetic dominance (the "fight-or-flight" response)
The effects were most pronounced in overweight and obese individuals and when combined with lifestyle modifications like diet and exercise
In high-dose macrodosing, side effects like vomiting or diarrhea are common
Ultimately, this review challenges the general strategy that the skin wound healing (Seiwerth et al., 1997
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