Regardless of form, sustained use appears more important than any single dose
Eisenberg T, Knauer H, Schauer A, Bttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity
THC & Cannabis products THC and cannabis products, similar to alcohol, decrease motivation and the desire to make lifestyle changes that are beneficial for treating mental health conditions and probably cause some depression and anxiety as well
Science (2021) 4
Clinical trials have demonstrated average weight loss of 15-22% of body weight over 68-72 weeks with semaglutide and tirzepatide, significantly exceeding results from lifestyle modification alone