glp-1 receptor list agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal Glucagon-like peptide-1 - Wikipedia

In practice, only 1013% of patients reach maximum doses

The mechanisms underlying weight regain are multifactorial and include metabolic adaptation with decreased energy expenditure, hormonal changes affecting appetite regulation, anatomical alterations such as gastric pouch or stoma dilation, and psychosocial factors including maladaptive eating behaviors

[Crossref] [PubMed] Mollan SP, Mitchell JL, Yiangou A, et al

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Furthermore, GLP-1 has been shown to have neuroprotective properties , including anti-inflammatory effects and promotion of neuronal survival