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Changes in Anthropometry and Cardiometabolic Parameters at Week 68 in Studies 2, 3, and 4 Missing data were imputed from retrieved subjects of the same randomized treatment arm (RD-MI) 1 Model based estimates based on an analysis of covariance model including treatment (and stratification factors for Study 3 only) as a factor and baseline value as a covariate 2 Not included in the pre-specified hierarchical testing (except HbA 1c for Study 3) 3 Model based estimates based on a mixed model for repeated measures including treatment (and stratification factors for Study 3 only) as a factor and baseline values as a covariate 4 Baseline value is the geometric mean Table 11

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While current research shows no definitive link between medication and depression in individuals without pre-existing conditions, careful monitoring and open communication with healthcare providers remain essential components of successful treatment

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