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We did not try to quantify the effect of exendin, ProGIP, and SC203972 on the positive inotropic effect of retatrutide because we later noticed that retatrutide was more effective in the presence of the phosphodiesterase III-inhibitor cilostamide

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Mechanistically, these agents have been shown to improve mitochondrial function and enhance cellular survival pathways in various cardiac and metabolic diseases [6]