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Additionally, CAFs directly participate in immune modulation by secreting immunosuppressive cytokines such as TGF- CXCL12, and IL-6, which promote the expansion of immunosuppressive cell populations, including Tregs and myeloid-derived suppressor cells (MDSCs), and suppress CD8+ T cells, natural killer (NK) cells, and dendritic cells (DCs) (142144)
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