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sALS and fALS progression is clinically and pathologically very similar, both characterized by the progressive accumulation of toxic misfolded protein aggregates within cells [76] and the significant loss of MNs [77]
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Intracellularly, 5-methylTHF functions as a methyl donor for homocysteine (hcy) remethylation, a reaction catalyzed by the methionine synthase (MTR) enzyme that transfers a methyl group from 5-methylTHF to hcy, forming tetrahydrofolate (THF) and methionine
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