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For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24
On each dosing day, subjects fasted overnight for at least 8 h before oral semaglutide dosing followed by either 15, 30, 60 or 120 min post-dose fasting until ingestion of a standardised breakfast (2335 kJ, 49 E% carbohydrate, 34 E% fat and 17 E% protein) including 250 mL liquid
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