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There is a continuum of perforation from micro perforation, which is presumably an igniting step in acute diverticulitis and which occurs well before there is evolution to a visible peridiverticular abscess
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Proper diagnosis, dosage, and monitoring are critical, as these medications may not be suitable for everyone and can have side effects or interactions with other treatments
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The next step known as the expansion phase where some of the melanocytic nevi progress into intermediate lesions and overtime develop into melanoma in situ , that is accompanied with the acquisition of the TERT promoter mutations, and a high mutational burden (6, 24, 25, 31)
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