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Scientists can also make synthetic peptides in the lab
H.MurrayJ
147 , 148 Specifically, substances with the greatest ability to pass through the BBB generally have a log octanol-water coefficient between 0.5 and 6.0 149 and a molecular mass of less than 400 to 500 daltons and do not form hydrogen bonds with water
Methylation of either of the nitrogen atoms in the imidazole rings of the histidine residues 6, 13 and 14 prevents formation of bridging histidine moieties
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