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Study Duration: DSIP may be administered on as-needed basis Notes: One 5mg spray bottle comprises 100 sprays, so would last just under 17 days of administration per test subject

Ethics statement The animal study was reviewed and approved by the Laboratory Animal Welfare and Ethics Committee of Fourth Military Medical University

AOD 9604 primarily affects pathways associated with lipid metabolism, including 3-adrenergic receptor signaling, cyclic AMPmediated cascades, and enzyme systems involved in lipolysis and lipogenesis

Engages antioxidant-response networks, including superoxide dismutase and proteasome-associated gene expression