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A one-year reduction in patent exclusivity on a blockbuster molecule with USD 5 billion in annual sales reduces the assets NPV by approximately USD 2-3 billion at a 10% discount rate, depending on the competitive landscape at the time of patent expiry and the rate of generic or biosimilar penetration

The limitation in this study is that GSH measurements are carried out through venous blood samples not through skin biopsy in melasma, because they are invasive

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Rodriguez-Morales AJ, Cardona-Ospina JA, Gutirrez-Ocampo E, Villamizar-Pea R, Holguin-Rivera Y, Escalera-Antezana JP, et al

Resting state brain networks under inverse agonist versus complete knockout of the cannabinoid receptor 1