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Unadjusted analysis found relatively higher (4 and 5.4% additional) weight loss, HbA1c (0.4% additional) reduction, and fewer gastrointestinal side effects with tirzepatide 10 and 15 mg, respectively, than with semaglutide 2.4 mg [25]
Prez-Oliva JF et al
Call your healthcare provider if you have any of the following symptoms: pain in your upper stomach (abdomen), fever, yellowing of your skin or eyes (jaundice), or clay-colored stools depression or thoughts of suicide
This combination data is largely preclinical and short-term and has not been validated in large human trials
The only exception, says Seltzer, is if youre taking it for a medical reason, like for a heart condition, and your cardiologist wants you to start at a higher dose for that purpose
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