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The RDA for Vitamin B12 for adults is set to 2.4 mcg (2.6 mcg in pregnancy and 2.8 mcg while breastfeeding) and represents the amount needed to prevent a damaging Vitamin B12 deficiency

Strong target identification normally requires orthogonal evidence such as direct binding, receptor-specific functional assays, selective antagonism, genetic loss of function, rescue experiments, and biophysical or chemical target-engagement analysis

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In such cases, intramuscular injections may be a better choice

Might be best to start a new thread if you do update as posts on older threads may get missed