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4-octyl itaconate and dimethyl fumarate induce secretion of the anti-inflammatory protein annexin A1 via NRF2

(Serotonin is another neurotransmitter that is an indoleamine.) The amino acid tryptophan (found in meats, dairy, and some grains) is converted by the enzyme tryptophan-5-hydroxylase to form 5-hydroxytryptophan, which is then converted to 5-hydroxytryptamine (aka serotonin !)

Others, like NAION, may cause irreversible vision loss

Second, we included events with a nonprimary diagnosis for DKA, severe hypoglycemia, MACEs and individual cardiovascular events

If you are ever unsure, consult your pharmacist or healthcare provider