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For example, intranasal administration of edaravone PLGA nanoparticles showed improved brain stability and bioavailability and reduced H 2 O 2 -induced oxidative stress toxicity in mouse microglial cell line BV-2 (Lu et al., 2023)

The research also highlights why Parkinsons disease is increasingly viewed as a disorder involving the whole body rather than only the brain

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The prefrontal cortex is highly sensitive to DA and even minor fluctuations can impair prefrontal cortex-dependent functions, making it particularly relevant in PTSD, as it plays a central role in suppressing fear responses, regulating stress reactivity, and enabling emotional control (Cools and D'Esposito, 2011)