Both semaglutide and tirzepatide are typically administered as a once-weekly injection
In the central nervous system, GLP-1Rs are located in numerous regions and it is suggested that GLP-1RAs act to promote weight loss through distributed effects rather than a specific or localized response [41]
[Crossref] Liang Y, Tian R, Wang J, Shan Y, Gao H, et al
It is very important for doctors and nurses to keep an eye on patients who are taking GLP-1 receptor agonist drugs for any signs of stomach problems, such as sickness, vomiting, bloating, and feeling full before they should

Short-Acting vs Long-Acting Formulations Short-acting GLP-1 medications have shorter half-lives and more frequent dosing: Exenatide immediate-release (Byetta) Half-life of approximately 24 hours, administered twice daily Lixisenatide (Lyxumia) Half-life of approximately 3 hours, administered once daily [19] Long-acting formulations demonstrate markedly different pharmacokinetics: Semaglutide Half-life of approximately 7 days (168 hours), administered weekly Dulaglutide Half-life of approximately 5 days (120 hours), administered weekly Liraglutide Half-life of approximately 13 hours, administered daily Exenatide extended-release Half-life of approximately 2 weeks, administered weekly Clearance Pathways GLP-1 medications are eliminated from the body through different pathways depending on the specific agent: Exenatide and lixisenatide are primarily eliminated through the kidneys