To date, there has not been one single proven explanation for experiencing headaches while using semaglutide, but here are some reasons why they might occur while using the medication
Kong Q, Zou J, Zhang Z, Pan R, Zhang ZY, Han S, Xu Y, Gao Y, Meng ZX (2022) BAF60a deficiency in macrophage promotes diet-induced obesity and metabolic inflammation
moderate evidence] Research suggests that these sweeteners partially activate the food reward pathway responsible for cravings:The Yale Journal of Biology and Medicine 2010: Gain weight by going diet? Artificial sweeteners and the neurobiology of sugar cravings [overview article
So those are some of my favorites
HUBERMAN: The differences between the two relate to small differences in the amino acid sequence for one peptide versus the other