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In clinical trials conducted using the once to weekly subcutaneous semaglutide injection, combined with lifestyle interventions, participants treated with semaglutide demonstrated greater reductions in body weight at least 15 percent of their baseline body weight compared to those who received a placebo

But even as far back as 1995, as Knudsens team was screening some of their early designs in mice, they saw that in addition to increasing insulin secretion, GLP-1 agonists made them eat less