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However, the introduction of semaglutide tablets and the development of higher-dose oral formulations have expanded therapeutic options

What would be interesting to see is if this effect is independent of weight loss

While many people begin retatrutide at a similar low dose, the exact starting approach can vary based on factors like medication sensitivity, prior experience with injectable therapies, and overall tolerance

Structure Therapeutics reported Phase 2 data in March 2026 from its aleniglipron programme showing weight loss of up to 16.3% at 44 weeks, the highest efficacy yet reported for an oral small-molecule GLP-1 receptor agonist at that time point

The CCK-2 receptor is encoded by the CCKBR gene