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Additionally, significant changes were noted in the composition of the bone matrix of these animals, with decreased enzymatic cross-linking of the collagenous matrix, which clearly worsened the compromised biomechanical strength and contributed to the observed bone fragility [44]
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Indeed, SLFN4 knockdown experiments have shown that inhibition of this protein diminishes the immunosuppressive properties of MDSCs, reducing levels of Arg-1 and iNOS, and consequently restoring T cell function [57]
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