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Int J Mol Sci 22:4416 Op den Kamp YJM, de Ligt M, Dautzenberg B, Kornips E, Esterline R, Hesselink MKC, Hoeks J, Schrauwen-Hinderling VB, Havekes B, Oscarsson J, Phielix E, Schrauwen P (2021) Effects of the SGLT2 inhibitor dapagliflozin on energy metabolism in patients with type 2 diabetes: a randomized, double-blind crossover trial
Third, it far exceeds all currently approved obesity medications
Clinical trials have not identified heart failure as a significant adverse event, and the SUSTAIN-6 trial demonstrated cardiovascular benefits rather than harm
Study: Increase in circulating GLP-1 following low FODMAP diet in irritable bowel syndrome patients
Lancet Diabetes Endocrinol 13:2937 Brush M, Auh S, Cochran E et al (2025) Effects of metreleptin in patients with generalized lipodystrophy before vs after the onset of severe metabolic disease
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