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When the EVOKE and EVOKE+ trials failed to meet their primary cognitive endpoints, some headlines framed the outcome as a major blow to the idea that GLP-1 medications could meaningfully impact Alzheimers disease
Hippocampus 24, 239248
Undergoing treatment via IV or injection is ideal because glutathione is not readily absorbed by the body
Continuous GLP-1RA use for three years was associated with the greatest reduction in MACE risk compared with sulfonylureas, whereas interruptions and discontinuations were associated with a progressive attenuation of this protective effect, with risk estimates in some scenarios approaching those of the comparator group
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