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Key takeaways Phendimetrazine and phentermine are prescription weight-loss medications that work as appetite suppressants and are used to treat obesity, but they differ in dosage forms, age restrictions, and controlled substance classifications

Gallbladder and biliary disease Several meta-analyses have found that GLP-1 agonists carry a modest increase in the risk of gallbladder or biliary disease (such as gallstones and cholecystitis), especially at higher doses, over longer durations, and when used mainly for weight loss [3]

The various responses on GLP-1 RAs in patients with T2DM or obesity or both, and even additional comorbidities, must be more thoroughly examined

Serious side effects are rare