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The clinical trials available do suggest a skin-lightening effect, but the long-term safety and efficacy of high doses have not been extensively studied

The formation of fibrils can also result in products with lower strengths than expected or indicated on the label, it says

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Table 24a Severity scores 6 days post injections of subcutaneous tissue necrosis for histidine-buffered co-formulations Table 24b Severity scores 6 days post injections of subcutaneous tissue necrosis for citrate-buffered co-formulation vehicles Concluding Remarks The results presented in table 24a show that the type of tonicity agent included in the formulation affects its in vivo local tolerability

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